Giles F. MacDonald, M.D.; Richard W. Hill, M.D., F.A.C.P.
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Observation of a 57-year-old woman known to have had rheumatoid arthritis, scleroderma, and polymyositis at the time lymphosarcoma developed in association with a leukemic blood picture prompted a retrospective study of this problem.
Twenty-nine cases, selected because histologic, serologic, or roentgenographic studies had confirmed diagnoses of both a collagen disease and a malignant lymphoma, were reviewed. Two groups were delineated. Group 1 consisted of 17 patients with rheumatoid arthritis, 2 with systemic lupus erythematosus, 1 with dermatomyositis, 1 with scleroderma, and 1 with rheumatoid spondylitis; a malignant lymphoma developed subsequently in all 22 patients. Group 2 consisted of 5 patients
MacDonald GF, Hill RW. Malignant Lymphoma Associated with Collagen Disease.. Ann Intern Med. ;66:1042–1043. doi: 10.7326/0003-4819-66-5-1042_3
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Published: Ann Intern Med. 1967;66(5):1042-1043.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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