Elliott F. Osserman, M.D.
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Lysozymes (LZM), discovered by Fleming, are low-molecular-weight (MV ≅ 14,000) basic proteins (isoelectric point, p1 ≅ 10.5) with the property of enzymatically splitting polysaccharides in the cell walls of many bacteria. Normally in man the highest concentrations of LZM are in tears, saliva, bronchial secretions, and leukocytes.
We have recently found that monocytic leukemia (ML) in man is associated with the production of extremely large quantities of LZM (J. Exp. Med. 124: 921, 1966). In 15 consecutive cases, the serum LZM levels (50 to 200 µg/ml) were 10 to 30 times normal (5 to 7 µg/ml) and the urine levels
Elliott F. Osserman. Lysozyme and Monocytic Leukemia.. Ann Intern Med. 1967;66:1043. doi: 10.7326/0003-4819-66-5-1043_1
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Published: Ann Intern Med. 1967;66(5):1043.
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