Herbert H. Spencer, M.D. (Associate); C. J. D. Zarafonetis, M.D., F.A.C.P.; W. H. Starkweather, M.S.
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Normal human lymphocytes and granulocytes have specific lactate dehydrogenase (LDH) isoenzyme patterns. When leukemic cells were studied, changes in the isoenzymes were observed that appeared to be of prognostic value during chemotherapy. In 15 cases, during the transition of chronic granulocytic leukemia to the acute phase, a significant drop in LDH-5 occurred, with a concomitant increase in the relative amounts of LDHl, -2, and -3. The pattern of change in the isoenzymes depended upon the degree of cellular differentiation present while the total cellular LDH activity decreased. In the terminal blast phase of the disease, an intermediate isoenzyme pattern with
Spencer HH, Zarafonetis CJD, Starkweather WH. Alterations of Lactate Dehydrogenase Isoenzymes During Therapy Directed at Leukemia.. Ann Intern Med. ;66:1044–1045. doi: 10.7326/0003-4819-66-5-1044_3
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Published: Ann Intern Med. 1967;66(5):1044-1045.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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