David T. Smith, A.B., M.D., D.Litt. (Hon.), F.A.C.P.
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Fifty years ago almost everyone over 20 years of age had been infected with human tubercle bacilli and gave strong positive skin reactions to standard doses of tuberculin. At the present time only 5% of Navy recruits and 15% of second year medical students give positive reactions to the same size dose of tuberculin.
This dramatic reduction in the prevalence of infection with the human tuberculin bacilli made possible the detection of widespread subclinical infection with atypical mycobacteria. Skin tests with purified protein derivatives made from the atypical organism suggest that approximately 15% of Navy recruits and medical students have
Smith DT. The James D. Bruce Memorial Award Lecture: The Influence of Subclinical Infections with Atypical Mycobacteria on the Diagnostic and Prognostic Significance of Quantitative Tuberculin Tests.. Ann Intern Med. 1967;66:1048–1049. doi: 10.7326/0003-4819-66-5-1048_3
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Published: Ann Intern Med. 1967;66(5):1048-1049.
Infectious Disease, Mycobacterial Infections.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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