Robert H. Frankenfeld, M.D., F.A.C.P.
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Pulmonary edema is a derangement of fluid balance in the pulmonary vasculature with causes and mechanisms more complex than mere failure of the left ventricle. Indeed, many instances occur in the presence of a normal heart. One of the unusual causes of pulmonary edema is sensitivity to nitrofurantoin. This is a specific response to this drug and is not related to other pulmonary reactions to drugs, such as asthma or pulmonary infiltration with eosinophilia.
Five patients with this reaction are described, two of whom underwent hemodynamic study. The typical reaction consists of fever and pulmonary edema and is frequently confused
Frankenfeld RH. Pulmonary Edema Caused by Nitrofurantoin.. Ann Intern Med. ;66:1055. doi: 10.7326/0003-4819-66-5-1055_2
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Published: Ann Intern Med. 1967;66(5):1055.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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