José Ramirez-R., M.D., F.A.C.P.
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The mechanisms responsible for the accumulation and clearing of the alveolar material in alveolar proteinosis have not been systematically studied, and the nature of this material is still a subject of speculation.
This paper presents a synthesis of multidisciplinary studies undertaken, with the collaboration of many investigators, to elucidate these problems. The studies were performed on nine cases of alveolar proteinosis observed clinically over a period of 2 to 5 years. Pulmonary biopsies were performed in six cases, 1 to 8 weeks after bronchopulmonary irrigation, while resolution of the pulmonary infiltrates was occurring. Pulmonary lipid metabolism was studied in vivo
Ramirez-R. J. Pulmonary Alveolar Proteinosis: An Inquiry on Its Pathogenesis.. Ann Intern Med. ;66:1056. doi: 10.7326/0003-4819-66-5-1056_2
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Published: Ann Intern Med. 1967;66(5):1056.
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