James P. Smith, M.D.; Richard W. Stone, M.D.; Carl Muschenheim, M.D., F.A.C.P.
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Mortality from acute respiratory failure in patients with chronic obstructive lung disease remains high (18 to 70%) in reported series. The possibility that the discouraging results of treatment are related in part to the widely recommended use of mechanical respirators has prompted an evaluation of a more conservative approach to therapy in patients with severe failure (Paco2, 55 mm Hg or more; arterial pH, 7.35 or less; and arterial oxygen saturation (SaO2), 85% or lower).
Precisely controlled oxygen, delivered according to the principle of high airflow with oxygen enrichment (Ventimask), and intensive supportive measures are used as initial therapy for
Smith JP, Stone RW, Muschenheim C. Management of Acute Respiratory Failure in Bronchitis and Emphysema with Observations on Controlled Oxygen Therapy.. Ann Intern Med. 1967;66:1056–1057. doi: 10.7326/0003-4819-66-5-1056_3
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Published: Ann Intern Med. 1967;66(5):1056-1057.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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