Frank A. Graig, M.D., F.A.C.P.; F. Michael Jacobius, M.D.
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Elevation of several serum enzymes (lactic dehydrogenase, glutamic-oxaloacetic transaminase, and creatine phosphokinase) was noted in 50% of patients when serum potassium levels were below 3 mEq/liter. The elevation of enzyme levels was independent of the etiology of hypokalemia, occurring with or without clinical muscle weakness or characteristic electrocardiographic changes. Successful potassium replacement was associated with a rapid fall of enzymes to normal levels. Although isoenzyme studies were not performed, no other apparent reason was found for the elevated serum enzyme levels. The findings are consistent with the hypothesis that the ratio of intracellular-extracellular potassium (K,/Ke) is crucial for the integrity
Graig FA, Jacobius FM. Elevated Serum Enzyme Levels Associated with Hypokalemia.. Ann Intern Med. 1967;66:1059. doi: 10.7326/0003-4819-66-5-1059_2
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Published: Ann Intern Med. 1967;66(5):1059.
Endocrine and Metabolism, Fluid and Electrolyte Disorders, Nephrology.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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