Julian G. Snyder, Ph.D., M.D., F.A.C.P.; Daniel Deykin, M.D.
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Defective lipoprotein lipase activity, measured by in vitro lipolysis of standardized lipid emulsions, has been postulated as a cause of certain forms of hyperglyceridemia. However, the relevance of in vitro assays of heparin-activated lipoprotein lipase to lipolysis in vivo has not been established. The present study was designed to correlate the in vitro and in vivo lipolytic responses to heparin.
Fasted male rabbits were anesthetized with pentobarbital (Nembutal®). Thirty minutes later, intravenous heparin in doses ranging from 0.06 mg/kg of body weight to 2.0 mg/kg of body weight was administered. Blood samples were removed before and at intervals after the
Snyder JG, Deykin D. A Quantitative In Vitro and In Vivo Study of Heparin-activated Lipolysis.. Ann Intern Med. ;66:1062. doi: 10.7326/0003-4819-66-5-1062_1
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Published: Ann Intern Med. 1967;66(5):1062.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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