R. A. O'Reilly, M.D., F.A.C.P.; P. M. Aggeler, M.D., F.A.C.P.
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To study the impact of albumin binding on drug action we have used the coumarin anticoagulant, warfarin sodium, as a model because of the ease with which the drug itself and its biologic effect of hypoprothrombinemia can be quantitated in man. By use of electrochromatography and cellulose acetate electrophoresis the warfarin in plasma, after oral administration, was found to be bound exclusively to the albumin fraction. To determine the strength and the number of these binding sites, this interaction was studied by equilibrium dialysis with crystalline preparations of human albumin and warfarin sodium. The albumin showed a single, strong, primary
O'Reilly RA, Aggeler PM. The Importance of Albumin Binding on Drug Action.. Ann Intern Med. ;66:1062–1063. doi: 10.7326/0003-4819-66-5-1062_3
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Published: Ann Intern Med. 1967;66(5):1062-1063.
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