THOMAS C. HALL, M.D., F.A.C.P.; OCK SOON CHOI, M.D.; ARDESHIR ABADI, M.D.; MELVIN J. KRANT, M.D.
The activity of the adrenal cortex may have a profound influence on the normal maintenance of lymphoid tissue. Dougherty and White (1) demonstrated, in 1943, that adrenocorticotrophic hormone (ACTH) caused lymphoid atrophy in mice. In 1944 Heilman and Kendall (2) reported that the administration of Compound E® (11-dehydro-17-hydroxycorticosterone) resulted in regression of lymphosarcoma implanted in female mice. Thereafter corticosteroid therapy was widely used in acute and chronic leukemia. Pearson and associates (3, 4), Spies and coworkers (5), and Stickney, Heck, and Watkins (6) observed transient regressions of lymphadenopathy in Hodgkin's disease after the administration of ACTH and low doses of
HALL TC, CHOI OS, ABADI A, KRANT MJ. High-Dose Corticoid Therapy in Hodgkin's Disease and other Lymphomas. Ann Intern Med. ;66:1144–1153. doi: 10.7326/0003-4819-66-6-1144
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Published: Ann Intern Med. 1967;66(6):1144-1153.
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