DARWIN J. PROCKOP, M.D., PH.D.; KARI I. KIVIRIKKO, M.D.
Essentially all the hydroxyproline in the tissues of vertebrates is found in collagen, and, except for the small amount of hydroxyproline in elastin, no other animal protein contains significant amounts of this amino acid (1). As has been recognized for over a decade, the relatively unique distribution of hydroxyproline among proteins makes this amino acid a useful, naturally occurring label for studying the metabolism of collagen. During recent years increasing interest has been directed toward the assay of hydroxyproline in urine, since it has been found that the excretion of hydroxyproline can be used to follow changes in the metabolism
PROCKOP DJ, KIVIRIKKO KI. Relationship of Hydroxyproline Excretion in Urine to Collagen Metabolism: Biochemistry and Clinical Applications. Ann Intern Med. ;66:1243–1266. doi: 10.7326/0003-4819-66-6-1243
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Published: Ann Intern Med. 1967;66(6):1243-1266.
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