JAY N. COHN, M.D., F.A.C.P.
Recent hemodynamic studies in a number of centers have prompted revision of the older concept that blood volume should be expanded only to replace obvious losses. It has now been clearly established that the vast majority of patients with shock, oliguria, or peripheral circulatory failure responds well to aggressive volume expansion, even when there is no demonstrable site for blood or plasma loss (1-3). Such functional deficits in blood volume are presumably related to intravascular or extravascular sequestration that may accompany fever, septicemia, myocardial infarction, infusion of sympathomimetic drugs (4), or any illness associated with intense reflex sympathoadrenal discharge (5).
JAY N. COHN. Central Venous Pressure as a Guide to Volume Expansion. Ann Intern Med. 1967;66:1283–1287. doi: 10.7326/0003-4819-66-6-1283
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Published: Ann Intern Med. 1967;66(6):1283-1287.
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