WILL G. RYAN, M.D.
Elsewhere in this issue of the ANNALS, Ludwig, Chaykin, and Escueta (1) describe an unusual patient whose clinical features resemble those of a group reported by Sotos and associates (2) in 1964. Sporadic case reports have appeared (3), and recently Poznanski and Stephenson (4) described the radiographic features of ten additional patients.
The syndrome of cerebral gigantism consists essentially of excessively rapid growth in childhood (probably beginning prenatally) with development of acromegalic features and a nonprogressive cerebral disorder associated with mental retardation and communicating hydrocephalus, in the presence of a radiologically normal sella turcica. The characteristic craniofacial configuration consists of
RYAN WG. Cerebral Gigantism—Inappropriate Secretion of Growth Hormone?. Ann Intern Med. 1967;67:212–213. doi: 10.7326/0003-4819-67-1-212
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Published: Ann Intern Med. 1967;67(1):212-213.
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