WILLIAM G. MCGEHEE, M.D.; SAMUEL I. RAPAPORT, M.D., F.A.C.P.; PETER F. HJORT, M.D.
Acute meningococcal infection in man pursues a variable course; usually the patient survives a severe illness characterized by a petechial skin eruption, meningitis, and a rapid response to appropriate antimicrobial therapy. However, an occasional unfortunate victim may die in profound and unresponsive shock hours after the onset of illness despite prompt and "adequate" treatment. Intravascular deposits of fibrin have been found at autopsy in such patients (1, 2), which suggests that diffuse intravascular coagulation could contribute to the clinical manifestations of meningococcal infection.
Intravascular coagulation produces characteristic platelet and clotting factor changes. Therefore, we have measured platelet and clotting factor
MCGEHEE WG, RAPAPORT SI, HJORT PF. Intravascular Coagulation in Fulminant Meningococcemia. Ann Intern Med. ;67:250–260. doi: 10.7326/0003-4819-67-2-250
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Published: Ann Intern Med. 1967;67(2):250-260.
Infectious Disease, Multi-Organ Failure and Sepsis, Pulmonary/Critical Care.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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