DONALD S. WALDORF, M.D.; HARLEY A. HAYNES, M.D.; EUGENE J. VAN SCOTT, M.D.
Mechlorethamine (nitrogen mustard, HN2) has been employed in the therapy of mycosis fungoides lymphoma for many years, most often by the intravenous route (1, 2). More recently, the agent has been shown to be effective when applied topically in nonvesicant doses to cutaneous lesions of the disease (3-7). Although development of cutaneous sensitivity to the drug in normal individuals is well-known (5, 8), the frequency of sensitization in patients with mycosis fungoides is alleged to be low (5).
The clinical study reported herein was prompted by the observation that allergic contact dermatitis to HN2 was induced in 11 of 16
WALDORF DS, HAYNES HA, VAN SCOTT EJ. Cutaneous Hypersensitivity and Desensitization to Mechlorethamine in Patients with Mycosis Fungoides Lymphoma. Ann Intern Med. ;67:282–290. doi: 10.7326/0003-4819-67-2-282
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Published: Ann Intern Med. 1967;67(2):282-290.
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