RALPH C. WILLIAMS JR., M.D.; JEFFREY L. ERICKSON, B.A.; HERBERT F. POLESKY, M.D.; WILLIAM R. SWAIM, M.D.
The occurrence of electrophoretically sharp, homogeneous serum proteins related to one of the immunoglobulin classes γG, γA, or γM (1) has generally been connected in the minds of clinicians with the distinct entities of multiple myeloma or Waldenström's macroglobulinemia. That such unique sharply defined proteins, termed M-components (2-4), are products of a presumably uniform or monoclonal cell population has been the concept generally held (5). It is also apparent that M-components may occur in association with diverse pathologic states, many neoplastic but others not directly associated with a malignant process (3, 5-11). In some instances M-components have been described in
WILLIAMS RC, ERICKSON JL, POLESKY HF, SWAIM WR. Studies of Monoclonal Immunoglobulins (M-Components) in Various Kindreds. Ann Intern Med. ;67:309–327. doi: 10.7326/0003-4819-67-2-309
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Published: Ann Intern Med. 1967;67(2):309-327.
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