HERBERT A. LUBS, M.D.; STUART KOTLER, M.D.
The chromosome complements of all well-studied human solid tumors have been abnormal. Similar tumors have been shown to have widely different types of chromosome abnormalities. This variation suggests that many tumors could be subgrouped by the type of cytogenetic abnormality present as well as by the presence or absence of specific marker chromosomes. Until recently, the number of adequately studied tumors of a given type has been too small to permit possible correlation of these subgroups with various clinical parameters such as the tendency to metastasize, response to therapy, or longevity. Two studies have recently been reported in which a
LUBS HA, KOTLER S. The Prognostic Significance of Chromosome Abnormalities in Colon Tumors. Ann Intern Med. ;67:328–336. doi: 10.7326/0003-4819-67-2-328
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Published: Ann Intern Med. 1967;67(2):328-336.
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