GERALD BURKE, M.D., C.M.
The long-acting thyroid stimulator (LATS) was first detected by Adams and Purves (1) who observed that the intravenous injection of serum from a patient with thyrotoxicosis caused a prolonged discharge of 131I from the thyroid glands of suitably prepared guinea pigs. The sustained time course of action of LATS was quite distinct from the relatively prompt and short-lived effects of pituitary thyrotropin and was the basis of the later, and now more widely used, bioassay procedure of McKenzie (2).
Recent observations that LATS is an immunoglobulin G (3-6) have led to the hypothesis that LATS is an antibody formed in
BURKE G. Dissociation Between Thyroid Injury and Formation of Long-Acting Thyroid Stimulator in Thyrotoxicosis. Ann Intern Med. ;67:349–355. doi: 10.7326/0003-4819-67-2-349
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Published: Ann Intern Med. 1967;67(2):349-355.
Endocrine and Metabolism, Thyroid Disorders.
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