STEPHEN F. BODMAN, M.D.; JOHN J. CONDEMI, M.D.
Excesses in both endogenous and exogenous adrenal corticosteroids result in the readily recognized clinical syndrome initially described by Cushing (1). An outstanding feature is the characteristic body habitus, a manifestation of central deposition of fat and loss of muscle mass. The basis for the central deposition of fat in the face, neck, and trunk under the influence of excess corticosteroids is not understood (2). This process also seems to be responsible for the recently described fatty episternal "dewlap" tumor developing in three patients receiving corticosteroids (3). While much emphasis has been placed on the changes in personal appearance, little emphasis
BODMAN SF, CONDEMI JJ. Mediastinal Widening in Iatrogenic Cushing's Syndrome. Ann Intern Med. ;67:399–403. doi: 10.7326/0003-4819-67-2-399
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Published: Ann Intern Med. 1967;67(2):399-403.
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