EUGENE P. CRONKITE, M.D.
Before one logically can consider perturbation of lymphopoiesis, immunity, or leukemic cell proliferation by killing cells in blood flowing through an extracorporeal radiation field, it is essential to understand the interrelations of blood and lymphatic lymphocytes or leukemic cells to their formative tissues. The notion of perturbing homeostasis in general by physical treatment (cold, radiation, etc.) of the blood flowing through an extracorporeal shunt was first published by Heymans (1) in 1921. However, it was not until a clear pattern of lymphocytic function, migration, and lifespan emerged that development of procedures to deplete the body of lymphocytes (analogous to hemorrhage
CRONKITE EP. Extracorporeal Irradiation of the Blood and Lymph in the Treatment of Leukemia and for Immunosuppression. Ann Intern Med. ;67:415–423. doi: 10.7326/0003-4819-67-2-415
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Published: Ann Intern Med. 1967;67(2):415-423.
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