HERBERT S. SISE, M.D., F.A.C.P.
The "Drug Explosion" has bred a litter of dilemmas. Simpler was life for the patient of yesteryear who was given a sugarcoated pill. Nowadays he emerges from the hospital, doctor's office, or clinic with pockets bulging with drugs. Some of these are drugs that though innocuous in solo can be lethal in concert. The most recent case of such drug interaction, demonstrated by Kristensen and Hansen (1), is a potentiation of the effect of tolbutamide by dicumarol.
Prompted by the observation of a hypoglycemic episode in a diabetic patient recently started on dicumarol, these investigators studied four diabetic patients who
SISE HS. Potentiation of Tolbutamide by Dicumarol. Ann Intern Med. ;67:460–461. doi: 10.7326/0003-4819-67-2-460
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Published: Ann Intern Med. 1967;67(2):460-461.
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