ROGER J. BULGER, M.D.
In the treatment of klebsiella pneumonia, authorities frequently recommend tetracycline, chloramphenicol, and combinations of streptomycin/tetracycline or streptomycin/chloramphenicol (1, 2). Many strains of Klebsiella are sensitive to cephalothin, and this agent has been used with increasing frequency in klebsiella pneumonias and urinary tract infections (3, 4). Benner, Mickelwait, Brodie, and Kirby (5) observed in vitro an extraordinarily rapid development of resistance to cephalothin by Klebsiella strains and predicted that increasing numbers of clinical isolates of Klebsiella would show resistance to cephalothin.
One of the advantages of antibiotic combinations is that they delay the emergence of resistant strains. Several studies have indicated that
BULGER RJ. In Vitro Effectiveness of Kanamycin and Kanamycin/Cephalothin Against Klebsiella: Comparison with Other Antibiotics. Ann Intern Med. ;67:523–532. doi: 10.7326/0003-4819-67-3-523
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Published: Ann Intern Med. 1967;67(3_Part_1):523-532.
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