JEROME I. BRODY, M.D., F.A.C.P.; FRANK OSKI, M.D.
The purpose of this study was to determine whether the immune indolence of the leukemic lymphocyte is complete or whether its failure to respond to stimuli is selective and depends upon the nature of the antigen to which the lymphocyte's host organism is exposed. Although the diminished in vivo and in vitro responses of the neoplastic lymphocyte to immunogenic and metabolic stimulants are acknowledged, the limits of this hyporeactivity and the extent of lymphocytic immunologic recall remain undefined. There is no established experimental evidence to support the concept that the leukemic lymphocyte's failure to synthesize in vivo antibody to one
BRODY JI, OSKI F. Immunologic Memory of the Normal and the Leukemic Lymphocyte. Ann Intern Med. ;67:573–578. doi: 10.7326/0003-4819-67-3-573
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Published: Ann Intern Med. 1967;67(3_Part_1):573-578.
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