GEORGE E. MCLAUGHLIN, M.D.; DANIEL J. MCCARTY JR., M.D., F.A.C.P.; D. F. DOWNING, M.D., F.A.C.P.
Hypertrophic osteoarthropathy associated with cyanotic congenital heart disease is a rare, poorly understood, but well-documented entity. Trever (1) reported 2 cases in 1958 and cited an incidence of 0.1% in a series of 3,000 cases of cyanotic heart disease. The clinical picture includes periosteal new bone formation, usually localized to the distal ends of the long bones, and overlying soft tissue neovascularization manifested by warmth, tenderness, and edema. When hypertrophic osteoarthropathy is associated with cyanotic congenital heart disease, clubbing of the digits has been a constant finding. The presence of synovitis, noted at necropsy in five of six cases of
MCLAUGHLIN GE, MCCARTY DJ, DOWNING DF. Hypertrophic Osteoarthropathy Associated with Cyanotic Congenital Heart Disease: A Report of Two Cases. Ann Intern Med. 1967;67:579–587. doi: 10.7326/0003-4819-67-3-579
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Published: Ann Intern Med. 1967;67(3_Part_1):579-587.
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