HERBERT E. KANN JR., M.D.; CHARLES E. MENGEL, M.D.; ROBERT L. WALL, M.D., F.A.C.P.
In paroxysmal nocturnal hemoglobinuria (PNH) the loss of iron in the urine in the form of hemoglobin or hemosiderin is primarily responsible for the unusually high incidence of iron deficiency that has been observed (1, 2). Although repletion of iron stores may result in significant improvement in the anemia of PNH, therapeutic replacement of iron can also constitute a special problem in this disease since iron administration may accelerate hemolytic activity (1, 3).
This relationship between iron and PNH hemolytic activity was demonstrated in a patient whom we have studied recently. His case was of particular interest since the iron
KANN HE, MENGEL CE, WALL RL. Paroxysmal Nocturnal Hemoglobinuria "Obscured" by the Presence of Iron Deficiency. Ann Intern Med. 1967;67:593–596. doi: 10.7326/0003-4819-67-3-593
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Published: Ann Intern Med. 1967;67(3_Part_1):593-596.
Hematology/Oncology, Red Cell Disorders.
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