JOHN H. VAUGHAN, M.D., F.A.C.P.; EUGENE V. BARNETT, M.D.; PETER J. LEADLEY, M.D.
Decline in the use of animal serums for therapy of human infections has meant that serum sickness has become a much less common illness than it was in the early part of this century. Nonetheless, serum sickness continues to attract investigational interest because it represents a well-defined model of allergic disease to which an ever-expanding battery of immunological tools can be applied. The case of serum sickness to be reported followed therapy for rabies. Advantage was taken of its occurrence to make several interesting immunological observations.
Experimental serum sickness has been related by Dixon (1) to the presence of antigen-antibody
VAUGHAN JH, BARNETT EV, LEADLEY PJ. Serum Sickness: Evidence in Man of Antigen-Antibody Complexes and Free Light Chains in the Circulation During the Acute Reaction. Ann Intern Med. ;67:596–602. doi: 10.7326/0003-4819-67-3-596
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Published: Ann Intern Med. 1967;67(3_Part_1):596-602.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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