ROBERT C. MILLER, B.S.; RICHARD M. GOODMAN, M.D.; FRANCES R. MILLER, B.A.; LANA NUSBAUM, B.S.
The abnormal karyotype (47/XXY) associated with the most common form of Klinefelter's syndrome was first observed by Jacobs and Strong (1) in 1959. Since then many cytogenetic variations have been noted, most of which involve polysomy of the X chromosome (2-4) or mosaicism (4-9). Other chromosomal variants of this syndrome include such alterations as polysomy of the Y chromosome (4, 7) and structural changes in one of the X chromosomes (4, 7, 9-11). One case has been reported involving a postulated break in the Y chromosome with translocation of its fragments to two other chromosomes (12).
The purpose of this
MILLER RC, GOODMAN RM, MILLER FR, NUSBAUM L. A New Variant of Klinefelter's Syndrome with a Presumptive Deleted Y Chromosome. Ann Intern Med. 1967;67:825–831. doi: 10.7326/0003-4819-67-4-825
Download citation file:
Published: Ann Intern Med. 1967;67(4):825-831.
Results provided by:
Copyright © 2018 American College of Physicians. All Rights Reserved.
Print ISSN: 0003-4819 | Online ISSN: 1539-3704
Conditions of Use