N. RAPHAEL SHULMAN, M.D.; DALE H. COWAN, M.D.; EUGENE P. LIBRE, M.D.; STANLEY P. WATKINS JR., M.D.; VICTOR J. MARDER, M.D.
Dr. N. Raphael Shulman: In the past few years much new information has been acquired concerning the pathophysiology and therapy of classic hemophilia and other diseases involving factor VIII deficiency. Most important has been a revolution in treatment permitted by the availability of factor VIII concentrates. Hemostasis in hemophiliacs, which several years ago presented a difficult if not hopeless problem, now can be managed with complete effectiveness in a rather routine manner. In addition, there is a clearer concept of the genetic control of factor VIII, provided chiefly by studies of von Willebrand's disease; and recently, there have been some
N. RAPHAEL SHULMAN, DALE H. COWAN, EUGENE P. LIBRE, STANLEY P. WATKINS, VICTOR J. MARDER. The Physiologic Basis for Therapy of Classic Hemophilia (Factor VIII Deficiency) and Related Disorders: Combined Clinical Staff Conference at the National Institutes of Health. Ann Intern Med. 1967;67:856–882. doi: 10.7326/0003-4819-67-4-856
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Published: Ann Intern Med. 1967;67(4):856-882.
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