ALLAN J. ERSLEV, M.D., F.A.C.P.; PATRICK J. MCKENNA, M.D.
In hereditary spherocytosis and in some cases of acquired hemolytic anemia splenectomy will remove the major site of red cell destruction and in turn increase the hemoglobin concentration and abolish the need for an accelerated rate of red cell production. In these conditions the immediate effect of splenectomy on red cell production is usually obscured by preoperative transfusions or by autotransfusions from the surgically manipulated spleen. The resulting increase in hemoglobin concentration would be expected to cause a prompt decrease in erythropoietic activity. In two recent cases, one of a patient with hereditary spherocytosis and the other of a patient
ERSLEV AJ, MCKENNA PJ. Effect of Splenectomy on Red Cell Production. Ann Intern Med. ;67:990–997. doi: 10.7326/0003-4819-67-5-990
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Published: Ann Intern Med. 1967;67(5):990-997.
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