FRED H. KATZ, M.D.
Primary aldosteronism is diagnosed with confidence if overproduction of aldosterone is associated with suppressed plasma renin activity (1). The anatomical finding of adrenocortical adenomas in such patients has been emphasized (2). Before the recognition of the importance of plasma renin determinations in making this diagnosis numerous cases of primary aldosteronism with bilateral adrenocortical hyperplasia rather than tumors were reported (3-5), although most patients had one or more adenomas. In the cases with hyperplasia, however, the diagnosis must now be questioned because the aldosteronism could be secondary to the overproduction of renin due to various causes (6).
This report describes a
KATZ FH. Primary Aldosteronism with Suppressed Plasma Renin Activity Due to Bilateral Nodular Adrenocortical Hyperplasia. Ann Intern Med. 1967;67:1035–1042. doi: 10.7326/0003-4819-67-5-1035
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Published: Ann Intern Med. 1967;67(5):1035-1042.
Adrenal Disorders, Endocrine and Metabolism, Endocrine Cancer, Hematology/Oncology.
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