KURT HIRSCHHORN, M.D.; MAIMON M. COHEN, PH.D.
The acute and the chronic psychotomimetic potentials of the hallucinogen lysergic acid diethylamide (LSD) have been documented (1). That additional effects of LSD should come under scrutiny at this time is particularly pertinent considering the supposed widespread use of this drug among the population. Recent investigations have demonstrated that small doses of LSD (as low as 0.001 µg/ml) yielded a two- to threefold increase of chromosomal damage in comparison with untreated control cells. A similar in vivo effect was predicted by the finding of increased chromosomal abnormalities in one patient receiving LSD therapy for a psychiatric disorder (2). This observation
HIRSCHHORN K, COHEN MM. Nonpsychic Effects of Lysergic Acid Diethylamide. Ann Intern Med. ;67:1109–1111. doi: 10.7326/0003-4819-67-5-1109
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Published: Ann Intern Med. 1967;67(5):1109-1111.
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