W. EDMUND FARRAR JR., M.D., F.A.C.P.; LAWRENCE C. DEKLE, A.B.
Shigellae resistant to multiple antibiotics were first encountered in Japan in 1955, shortly after the clinical use of streptomycin, tetracycline, and chloramphenicol became widespread in that country (1). Since this time many epidemics of shigellosis due to organisms resistant to these three antibiotics plus sulfonamides have occurred in Japan. This type of multiple drug resistance was found to be mediated by a cytoplasmic deoxyribonucleic acid (DNA) particle (R factor) that replicates independently of the host chromosome and can be transferred from cell to cell among various species of gram-negative bacilli (2). Since 1962 transferable antibiotic resistance has been demonstrated in
W. EDMUND FARRAR, LAWRENCE C. DEKLE. Transferable Antibiotic Resistance Associated with an Outbreak of Shigellosis. Ann Intern Med. 1967;67:1208–1215. doi: 10.7326/0003-4819-67-6-1208
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Published: Ann Intern Med. 1967;67(6):1208-1215.
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