JOSEPH F. FRAUMENI JR., M.D., F.A.C.P.; JOHN C. HERWEG, M.D.; JOHN M. KISSANE, M.D.
The etiology of nonsyphilitic inflammatory diseases of the aorta is unknown, although some cases occur in association with rheumatic or rheumatoid diseases (1). Recently, there have been reports of aortitis associated with malignant lymphoma in three young people. The aortitis in two instances was believed to result directly from radiation therapy of the lymphoma (2, 3), but in one case it developed before treatment (4). This report concerns a girl with Hodgkin's disease who developed aortitis and the relationship of this complication to radiation therapy and the lymphoma.
An 8-year-old white girl was well until September 1953, when
FRAUMENI JF, HERWEG JC, KISSANE JM. Panaortitis Complicating Hodgkin's Disease. Ann Intern Med. 1967;67:1242–1248. doi: 10.7326/0003-4819-67-6-1242
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Published: Ann Intern Med. 1967;67(6):1242-1248.
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