SUMNER C. KRAFT, M.D., F.A.C.P.
Many theories have been proposed to explain nonspecific ulcerative colitis, but the etiology and pathogenesis of this disease remain unknown. The possible involvement of immune mechanisms has received special attention in the past decade on the basis of largely presumptive evidence from clinical and laboratory studies (1).
Earlier investigations of ulcerative colitis from the immunologic point of view described a variety of circulating reactants in a relatively small percentage of patients with ulcerative colitis. However, antibodies to any antigen do not necessarily indicate an immunologically induced disease state (2), and it has not been possible to correlate clinical status with
KRAFT SC. Newer Approaches to Ulcerative Colitis. Ann Intern Med. ;67:1344–1346. doi: 10.7326/0003-4819-67-6-1344
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Published: Ann Intern Med. 1967;67(6):1344-1346.
Gastroenterology/Hepatology, Inflammatory Bowel Disease.
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