N. DAVID CHARKES, M.D.
To the Editor: Silverstein, Burke, and Cogan have provided valuable information on the natural history of so-called "hot" thyroid nodules in their recent paper in the ANNALS (The natural history of the autonomous hyperfunctioning thyroid nodule. Ann. Intern. Med. 67: 539, 1967). One may take issue with their statement, however, that in Case 2 "the 50% decrease in 131I uptake after 1-triiodothyronine (1-T3) administration suggests that, initially, intranodular function was partially TSH-dependent." In a recent study of 25 patients with autonomous, hyperfunctioning thyroid nodules, my colleagues and I observed that although a marked fall in the 24-hr epithyroid count may
CHARKES ND. AUTONOMOUS THYROID NODULES. Ann Intern Med. ;68:254–257. doi: 10.7326/0003-4819-68-1-254_2
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Published: Ann Intern Med. 1968;68(1):254-257.
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