PETER V. D. BARRETT, M.D.; PAUL D. BERK, M.D.; MATTHEW MENKEN, M.D.; NATHANIEL I. BERLIN, M.D.
Bilirubin-14C in tracer quantities was administered to 26 patients in 29 studies to determine the plasma bilirubin-14C specific activity disappearance rates. Unconjugated bilirubin was separated from the conjugated pigments by a solvent method. The plasma disappearance curve was found to take the form of the sum of two exponentials, the more rapid of which had an average half-life of 21.5 min. A multicompartmental model of bilirubin metabolism is proposed on the basis of the data, and calculations of bilirubin production and intercompartmental rate constants are made. A mechanism is postulated to explain the hyperbilirubinemia of Gilbert's disease. Eight patients were studied with a nonradioactive bilirubin infusion test, and the results were compared with the isotope studies. It is concluded that the bilirubin-14C method provided a more accurate evaluation of bilirubin production and of hepatic excretion patterns.
PETER V. D. BARRETT, PAUL D. BERK, MATTHEW MENKEN, NATHANIEL I. BERLIN. Bilirubin Turnover Studies in Normal and Pathologic States Using Bilirubin-14C. Ann Intern Med. 1968;68:355–377. doi: 10.7326/0003-4819-68-2-355
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Published: Ann Intern Med. 1968;68(2):355-377.
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