FRANKLIN H. EPSTEIN, M.D., F.A.C.P.
It has been known for many years that calcium and phosphorus metabolism may be profoundly disturbed in hyperthyroidism. Along with weight loss and wasting of tissues, a negative calcium balance is usual, contributed to by excessive excretion of calcium in the urine, the feces, or both (1). Hypercalcemia, usually with a normal or slightly elevated serum phosphorus, is occasionally encountered (2). Bone is the source of the excess calcium. The turnover of calcium by the skeleton is increased by thyroid hormone, and radiological signs of thinning of bone are not infrequent (3, 4).
Adams and Jowsey and their colleagues (5,
EPSTEIN FH. Bone and Mineral Metabolism in Hyperthyroidism. Ann Intern Med. 1968;68:490–491. doi: 10.7326/0003-4819-68-2-490
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Published: Ann Intern Med. 1968;68(2):490-491.
Endocrine and Metabolism, Thyroid Disorders.
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