HERMAN O. KLEIN, M.D.
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To the Editor: In the article "Valve Replacement During Pregnancy" (Ann. Intern. Med. 67: 1032, 1967) the authors point out the risk to the fetus attendant on the use of anticoagulants of the coumarin family. I wondered why, in the course of treatment of the patient under discussion, heparin was not substituted for warfarin till the twenty-eighth week of gestation. Was this due to an oversight or was this course of therapy chosen because of a rationale that I do not know? It would seem to me that, if heparin is preferred over the coumarin derivatives because of its higher
KLEIN HO. ANTICOAGULANTS AND VALVE REPLACEMENT DURING PREGNANCY. Ann Intern Med. ;68:495. doi: 10.7326/0003-4819-68-2-495_1
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Published: Ann Intern Med. 1968;68(2):495.
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