JOHN C. NORMAN, M.D.; VICTOR H. COVELLI, M.D.; HERBERT S. SISE, M.D., F.A.C.P.
On February 24, 1908, Alexis Carrel removed the spleen from a large yellow dog, "in poor health." The spleen was washed in and perfused with Locke's solution. After forty-four minutes, the spleen had been replaced [orthotopically] and circulation re-established. In June at re-exploration, the organ appeared normal. In November, following accidental death at the animal farm, "the histology of the [autotransplanted] spleen appeared normal." A companion experiment failed because of technical problems. Carrel stated that "from a surgical standpoint, the problem of the graft of organs (spleen and kidney) can be considered as having been solved. But, from a biological
NORMAN JC, COVELLI VH, SISE HS. Transplantation of the Spleen. Ann Intern Med. 1968;68:700–704. doi: 10.7326/0003-4819-68-3-700
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Published: Ann Intern Med. 1968;68(3):700-704.
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