PAUL P. CARBONE, M.D.
The development of infections in man by ordinarily nonpathogenic organisms represents a problem to the internist and the surgeon who manage patients with hematologic malignancies and renal transplants (1-3). In these complex clinical situations many factors, including the underlying disease process, the use of immunosuppressive drugs and corticosteroids, and leukopenia, have been implicated. Rarely can the pathogenesis of the infection be defined. However, in the latest of a series of papers by Epstein, Verney, Miale, and Sidransky (4), a very definitive analysis of the pathogenesis of experimental aspergillosis in mice has been suggested. Utilizing the cortisone-treated mouse as an experimental
CARBONE PP. Lysosomes, Cortisone, and Aspergillosis. Ann Intern Med. ;68:708–709. doi: 10.7326/0003-4819-68-3-708
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Published: Ann Intern Med. 1968;68(3):708-709.
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