GEORGE WALTUCH, M.D.; ANN K. LANZEROTTI, A.B.; STANLEY L. SCHRIER, M.D.
Marrow erythroblasts from three patients with a well-characterized anemia due to idiopathic ineffective erythropoiesis were studied. The erythroblasts from patients incorporated isotopically labeled valine as well as erythroblasts from normal controls. However, erythroblasts also incorporated labeled glycine less than one tenth as well as normal erythroblasts, and the pattern of incorporation was different. It was therefore proposed that the patient's erythroblasts had a defect in their heme synthetic pathway.
WALTUCH G, LANZEROTTI AK, SCHRIER SL. Marrow Defect in Idiopathic Ineffective Erythropoiesis. Ann Intern Med. ;68:1005–1012. doi: 10.7326/0003-4819-68-5-1005
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Published: Ann Intern Med. 1968;68(5):1005-1012.
Hematology/Oncology, Red Cell Disorders.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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