MARTIN S. HIRSCH, M.D.
To the Editor: In the editorial "Antilymphocyte Serum as an Immunosuppressive Agent" (Ann. Intern. Med. 68: 483, 1968), the author suggests that antilymphoid sera's ability to suppress host cellular responses without greatly affecting humoral defenses may be important in protecting the host against bacterial infection. Unfortunately, this characteristic of antilymphoid sera may not offer similar protection against certain viral infections where cellular responsiveness appears to be a major host defense mechanism (1). Several studies have shown that antilymphoid sera may potentiate multiplication and pathogenicity of viruses in experimental animals. Included among these are vaccinia, herpes simplex, polyoma, adenovirus, and the
HIRSCH MS. ANTILYMPHOCYTE SERUM. Ann Intern Med. ;68:1134–1135. doi: 10.7326/0003-4819-68-5-1134
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Published: Ann Intern Med. 1968;68(5):1134-1135.
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