Howard J. Schwartz, M.D.; Francis C. Lowell, M.D., F.A.C.P.; James C. Melby, M.D.
This content is PDF only. Please click on the PDF icon to access.
Relative resistance to corticosteroid therapy was observed in some asthmatic patients. The eosinopenic responses to 40 mg cortisol intravenously in 19 unselected asthmatics (group A) and 6 resistant asthmatics (group B) were measured by following changes in total eosinophil counts (TEC). The percent TEC changes were -35, -77, and -73 in group A and -10, -36, and +5 in group B at 2, 4, and 6 hr after administration. These differences were highly significant (P = 0.01) and independent of the base-line TEC.
Cortisol turnover studies in four subjects from each group were done. Each patient received a tracer dose
Howard J. Schwartz, Francis C. Lowell, James C. Melby. Steroid Resistance in Bronchial Asthma.. Ann Intern Med. 1968;68:1141. doi: 10.7326/0003-4819-68-5-1141_3
Download citation file:
Published: Ann Intern Med. 1968;68(5):1141.
Asthma, Pulmonary/Critical Care.
Results provided by:
Copyright © 2017 American College of Physicians. All Rights Reserved.
Print ISSN: 0003-4819 | Online ISSN: 1539-3704
Conditions of Use