Leon J. Marks, M.D., F.A.C.P.; Donald C. Nabseth, M.D.; Lester A. Klein, M.D.; Jesse Roth, M.D.; Botond Berde, M.D.
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A 59-year-old man with a bronchogenic carcinoma (oat cell) demonstrated inappropriate antidiuresis on the basis of  persistent urine hyperosmolality with marked serum hypoosmolality and hyponatremia in the presence of a normal blood volume,  correction of hyponatremia with water restriction, and  excessive natriuresis with normal renal and adrenal function. Resection of the primary lung tumor did not ameliorate the antidiuretic hormone syndrome. At autopsy, performed 4 months postoperatively, metastatic lung cancer was present in the liver, and a separate pancreatic tumor (adenocarcinoma) was found in the pancreas. Extracts of the pancreatic neoplasm contained very high levels of arginine
Leon J. Marks, Donald C. Nabseth, Lester A. Klein, Jesse Roth, Botond Berde. Inappropriate Antidiuretic Hormone Syndrome and Carcinoma of Pancreas with Demonstration of Tumor Antidiuretic Activity.. Ann Intern Med. 1968;68:1144–1145. doi: 10.7326/0003-4819-68-5-1144_3
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Published: Ann Intern Med. 1968;68(5):1144-1145.
Endocrine and Metabolism, Fluid and Electrolyte Disorders, Hematology/Oncology, Nephrology, Neurology.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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