A. Richard Christlieb, M.D.; Nathan P. Couch, M.D.; Ezra A. Amsterdam, M.D.; Saul J. Dobrzinsky, M.D.; Roger B. Hickler, M.D., F.A.C.P.
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Experimental studies in the dog indicate that the liver may be the major site of renin inactivation (Heacox and associates, Circ. Res. 21: 149, 1967). To apply this observation to humans, the hepatic and renal arteriovenous (AV) differences for renin activity were measured simultaneously in patients undergoing diagnostic venous catheterization. The plasma renin activity (PRA) was measured by a modification of the Boucher method. In 8 patients, renal venous PRA was higher than arterial PRA, indicating the renal secretion of renin into the circulation. In 6 of these, a wide renal AV difference was associated with a renal artery stenosis.
Christlieb AR, Couch NP, Amsterdam EA, Dobrzinsky SJ, Hickler RB. Renin Inactivation by the Human Liver.. Ann Intern Med. ;68:1146. doi: 10.7326/0003-4819-68-5-1146_2
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Published: Ann Intern Med. 1968;68(5):1146.
Gastroenterology/Hepatology, Liver Disease.
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