George D. Ludwig, M.D., F.A.C.P.; William Cushard, M.D.; Doris Bartuska, M.D.; Roberto Franco, M.D.; Louis Chaykin, M.D.
This content is PDF only. Please click on the PDF icon to access.
Although serotonin may be responsible for the diarrhea of the carcinoid syndrome, recent evidence suggests that bradykinen induces the flushes and the vascular phenomena. A rise in hepatic venous bradykinen concentration accompanying flushing has been demonstrated, and a specific kallikrein has been isolated from carcinoid cells. Catecholamines can induce flushing attacks. Since intravenous epinephrine is more effective than norepinephrine in this regard and since alpha-adrenergic blocking agents are ineffective in carcinoid patients, a study of the effect of beta blockade in the carcinoid syndrome seemed warranted. Studies were made in four patients with metastatic carcinoid from primary ileal carcinoids.
George D. Ludwig, William Cushard, Doris Bartuska, Roberto Franco, Louis Chaykin. Effects of Beta-Adrenergic Blockade in the Carcinoid Syndrome.. Ann Intern Med. 1968;68:1188. doi: 10.7326/0003-4819-68-5-1188_2
Download citation file:
Published: Ann Intern Med. 1968;68(5):1188.
Results provided by:
Copyright © 2017 American College of Physicians. All Rights Reserved.
Print ISSN: 0003-4819 | Online ISSN: 1539-3704
Conditions of Use