George D. Ludwig, M.D., F.A.C.P.; William Cushard, M.D.; Doris Bartuska, M.D.; Roberto Franco, M.D.; Louis Chaykin, M.D.
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Although serotonin may be responsible for the diarrhea of the carcinoid syndrome, recent evidence suggests that bradykinen induces the flushes and the vascular phenomena. A rise in hepatic venous bradykinen concentration accompanying flushing has been demonstrated, and a specific kallikrein has been isolated from carcinoid cells. Catecholamines can induce flushing attacks. Since intravenous epinephrine is more effective than norepinephrine in this regard and since alpha-adrenergic blocking agents are ineffective in carcinoid patients, a study of the effect of beta blockade in the carcinoid syndrome seemed warranted. Studies were made in four patients with metastatic carcinoid from primary ileal carcinoids.
Ludwig GD, Cushard W, Bartuska D, Franco R, Chaykin L. Effects of Beta-Adrenergic Blockade in the Carcinoid Syndrome.. Ann Intern Med. ;68:1188. doi: 10.7326/0003-4819-68-5-1188_2
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Published: Ann Intern Med. 1968;68(5):1188.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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