R. W. E. Watts, M.D., F.R.C.P.
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There is a continuous high urinary oxalate excretion in primary hyperoxaluria. Glycine is a metabolic precursor of oxalate, and the relative importance of the alternative metabolic pathways from glycine to oxalate have been studied in vivo using (1-13C) glycine and (2-13C) glycine. The results indicate that the main metabolic sequence is glycine → glyoxylate oxalate but that there is also a subsidiary contribution through the sequence glycine → serine → ethanolamine → glycolic aldehyde → glycolate glyoxylate → oxalate.
The metabolism of glyoxylate has been investigated in vitro in some human tissues. Kidney tissue from two patients with primary hyperoxaluria
Watts RWE. Metabolic Studies on Primary Hyperoxaluria.. Ann Intern Med. ;68:1191. doi: 10.7326/0003-4819-68-5-1191_1
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Published: Ann Intern Med. 1968;68(5):1191.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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