RICHARD M. FREEMAN, M.D.; RICHARD L. LAWTON, M.D.; MARGERY O. FEARING, R.N.
Gynecomastia was observed in 10 of 24 patients receiving maintenance hemodialysis. In nine patients, breast enlargement appeared 2 to 9 months after the beginning of twice-weekly hemodialysis. In one patient, gynecomastia was present before dialysis was started. Blood urea nitrogen and serum creatinine were the same in dialysis patients with gynecomastia as in the dialysis patients without gynecomastia. There was variation in degree and duration of gynecomastia. Gynecomastia was bilateral in nine patients. The following possible causes of gynecomastia do not appear to be responsible for dialysis-induced gynecomastia: drugs (methyldopa, digitalis, tranquilizers), liver disease, and malnutrition. Gynecomastia in dialysis patients clinically resembles "refeeding gynecomastia" observed after World War II. The physiologic mechanism for gynecomastia, however, is unknown.
FREEMAN RM, LAWTON RL, FEARING MO. Gynecomastia: An Endocrinologic Complication of Hemodialysis. Ann Intern Med. ;69:67–72. doi: 10.7326/0003-4819-69-1-67
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Published: Ann Intern Med. 1968;69(1):67-72.
Nephrology, Renal Replacement Therapy.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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