MARSHALL B. BLOCK
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To the Editor: I would like to disagree with a statement made by the authors of the paper entitled, "'Asymptomatic' Type I Dysgammaglobulinemia in Siblings" (Ann. Intern. Med. 68: 867, 1968).
They state in partial support for their argument that congenital hypogammaglobulinemia (Bruton type) is a distinct entity separable on genetic grounds from dysgammaglobulinemia type I, that "females with an antibody-deficiency syndrome have been reported." This in no way negates sex-linked inheritance as it is possible for a marriage of a female carrier and a male with Bruton's disease to produce a female with this disorder. Admittedly this would be
BLOCK MB. DYSGAMMAGLOBULINEMIA TYPE I. Ann Intern Med. 1968;69:403. doi: 10.7326/0003-4819-69-2-403_1
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Published: Ann Intern Med. 1968;69(2):403.
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